HitPredict

Interactor 1: PSA4 (P18053)
Proteasome subunit alpha type-4 (PROS-Dm29) (Proteasome 29 kDa subunit)
Gene: Prosalpha3

Interactor 2: PSA2 (P40301)
Proteasome subunit alpha type-2 (PROS-Dm25) (Proteasome 25 kDa subunit)
Gene: Prosalpha2

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	22036573, 19079254
Identification Methods	affinity chromatography technology, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005829 - cytosol GO:0005839 - proteasome core complex GO:0019773 - proteasome core complex, alpha-subunit complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 264 Dm			1 234
+	Sp
		293714 PSA3_SCHPO (1-250): 1.07e-92: 275: 52.38		PSA2_SCHPO (3-233): 1.96e-107: 311: 58.20
+	Dm
		574027 PSA4_DROME (1-264): 8.49e-97: 286: 100.00		PSA5_DROME (1-233): 1.55e-97: 286: 30.71
+	Hs
		638067 PSA4_HUMAN (1-240): 7.13e-96: 283: 72.92		PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38
+	Hs
		108927 H0YKT8_HUMAN (25-208): 1.3e-93: 275: 73.37		PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38
+	Hs
		637626 PSA4_HUMAN (1-240): 7.13e-96: 283: 72.92		PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11
+	Hs
		108925 H0YKT8_HUMAN (25-208): 1.3e-93: 275: 73.37		PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11
+	Hs
		637318 PSA4_HUMAN (1-240): 7.13e-96: 283: 72.92		PSA1_HUMAN (1-233): 5.72e-92: 272: 30.67
+	Hs
		638100 PSA4_HUMAN (1-240): 7.13e-96: 283: 72.92		PSA6_HUMAN (3-233): 6.35e-91: 269: 32.49
+	Hs
		156226 PSA4_HUMAN (1-240): 7.13e-96: 283: 72.92		PSA7_HUMAN (6-231): 9.41e-91: 268: 36.52
+	Hs
		637631 PSA5_HUMAN (3-243): 1.02e-90: 269: 31.30		PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11
+	Hs
		108924 H0YKT8_HUMAN (25-208): 1.3e-93: 275: 73.37		PSA1_HUMAN (1-233): 5.72e-92: 272: 30.67
+	Ce
		1278563 PSA4_CAEEL (1-240): 1.19e-92: 275: 65.83		PSA7_CAEEL (4-233): 8.57e-92: 271: 33.33
+	Hs
		108938 H0YKT8_HUMAN (25-208): 1.3e-93: 275: 73.37		PSA6_HUMAN (3-233): 6.35e-91: 269: 32.49
+	Ss
		94582 F1SBA5_PIG (1-237): 7.43e-91: 270: 32.49		F2Z5L7_PIG (1-233): 5.72e-92: 272: 30.67
+	Hs
		637325 PSA5_HUMAN (3-243): 1.02e-90: 269: 31.30		PSA1_HUMAN (1-233): 5.72e-92: 272: 30.67
+	Hs
		156230 PSA5_HUMAN (3-243): 1.02e-90: 269: 31.30		PSA7_HUMAN (6-231): 9.41e-91: 268: 36.52
+	Dm
		574012 PSA4_DROME (1-264): 8.49e-97: 286: 100.00		PSA71_DROME (3-230): 2.89e-44: 150: 36.48
+	Sp
		999716 PSA3_SCHPO (1-250): 1.07e-92: 275: 52.38		PSA4_SCHPO (6-214): 2.76e-48: 161: 37.92
+	Hs
		638061 PSA4_HUMAN (1-240): 7.13e-96: 283: 72.92		PSA4_HUMAN (3-217): 3.05e-44: 150: 39.64