Interactor 1: ERCC2 (P18074)
General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)
Gene: ERCC2

Interactor 2: MAT1 (P51948)
CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)
Gene: MNAT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.950

The method score is based on:

Property Details
Experiments 26186194, 28514442, 26340423, 32245994, 33961781, 10801852
Identification Methods affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HBB~MAT1
Common GO terms GO:0000439 - transcription factor TFIIH core complex
GO:0005654 - nucleoplasm
GO:0005675 - transcription factor TFIIH holo complex
GO:0006289 - nucleotide-excision repair
GO:0006357 - regulation of transcription by RNA polymerase II
and 2 others

more...

Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 760
Hs

1 309
+ Sc
+ Sp
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024