Interactor 1: ERCC2 (P18074)
General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)
Gene: ERCC2

Interactor 2: TF2H2 (Q13888)
General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit)
Gene: GTF2H2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.961

The method score is based on:

Property Details
Experiments 9771713, 26340423, 11062469, 10924514, 12820975, 8652557, 19934020
Identification Methods affinity chromatography technology, pull down, coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Helicase_C_2~Ssl1
Common GO terms GO:0000439 - transcription factor TFIIH core complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005669 - transcription factor TFIID complex
GO:0005675 - transcription factor TFIIH holo complex
and 4 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 760
Hs

1 395
+ Hs
+ At
+ Sc
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024