HitPredict

Interactor 1: ADA2B (P18089)
Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR)
Gene: ADRA2B

Interactor 2: ACKR3 (P25106)
Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor 159) (G-protein coupled receptor RDC1 homolog) (RDC-1)
Gene: ACKR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28862946
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	7tm_1~7tm_1
Common GO terms	GO:0001525 - angiogenesis GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 450 Hs			1 362
+	Hs
		537259 DRD2_HUMAN (15-443): 5.75e-83: 263: 27.67		SSR2_HUMAN (1-352): 2.57e-73: 233: 23.89
+	Rn
		675599 DRD2_RAT (15-443): 5.61e-82: 261: 27.91		SSR2_RAT (1-352): 1.49e-72: 231: 23.33
+	Hs
		537262 DRD2_HUMAN (15-443): 5.75e-83: 263: 27.67		OPRM_HUMAN (7-358): 1.1e-69: 225: 21.67
+	Rn
		550452 DRD4_RAT (25-441): 1.75e-73: 237: 29.67		ADA1B_RAT (7-334): 1.03e-67: 223: 14.78
+	Hs
		428917 DRD4_HUMAN (20-443): 4.96e-64: 214: 29.04		ADRB2_HUMAN (9-354): 5.3e-69: 224: 16.06
+	Hs
		602188 DRD4_HUMAN (20-443): 4.96e-64: 214: 29.04		ADA1B_HUMAN (4-334): 4.26e-67: 222: 13.80
+	Hs
		626811 ADA1A_HUMAN (312-449): 1.03e-28: 119: 26.09		ACKR3_HUMAN (1-362): 5.15e-76: 240: 100.00
+	Hs
		626812 ADA1B_HUMAN (359-443): 1.74e-28: 119: 42.35		ACKR3_HUMAN (1-362): 5.15e-76: 240: 100.00
+	Hs
		626675 ADA1D_HUMAN (350-437): 2.25e-25: 110: 44.32		ACKR3_HUMAN (1-362): 5.15e-76: 240: 100.00
+	Hs
		428883 ADRB1_HUMAN (353-443): 4.65e-28: 117: 41.94		ADRB2_HUMAN (9-354): 5.3e-69: 224: 16.06
+	Hs
		722929 ADA1A_HUMAN (312-449): 1.03e-28: 119: 26.09		ADA1B_HUMAN (4-334): 4.26e-67: 222: 13.80
+	Hs
		723007 ADA1B_HUMAN (359-443): 1.74e-28: 119: 42.35		ADA1B_HUMAN (4-334): 4.26e-67: 222: 13.80
+	Hs
		722928 ADA1A_HUMAN (312-449): 1.03e-28: 119: 26.09		ADA1A_HUMAN (23-343): 1.73e-66: 219: 15.99
+	Hs
		722931 ADA1A_HUMAN (312-449): 1.03e-28: 119: 26.09		CXCR4_HUMAN (15-338): 3.13e-67: 217: 28.09
+	Hs
		723008 ADA1B_HUMAN (359-443): 1.74e-28: 119: 42.35		CXCR4_HUMAN (15-338): 3.13e-67: 217: 28.09
+	Hs
		626678 ADA1D_HUMAN (350-437): 2.25e-25: 110: 44.32		ADA1B_HUMAN (4-334): 4.26e-67: 222: 13.80
+	Hs
		428881 ADRB2_HUMAN (350-449): 8.27e-25: 107: 31.00		ADRB2_HUMAN (9-354): 5.3e-69: 224: 16.06
+	Hs
		428952 ADRB2_HUMAN (350-449): 8.27e-25: 107: 31.00		OPRD_HUMAN (8-360): 2.32e-67: 218: 22.44
+	Mm
		578598 ADRB1_MOUSE (358-441): 1.45e-12: 71.2: 44.19		ADRB2_MOUSE (12-360): 1.18e-69: 225: 16.19