HitPredict

Interactor 1: EGR1 (P18146)
Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24)
Gene: EGR1

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: innatedb

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19032775
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~zf-C2H2
Common GO terms	GO:0005634 - nucleus GO:0010628 - positive regulation of gene expression GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 393
+	Hs
		575304 EGR1_HUMAN (1-543): 1.51e-146: 434: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		575275 EGR1_HUMAN (1-543): 1.51e-146: 434: 100.00		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		575289 EGR1_HUMAN (1-543): 1.51e-146: 434: 100.00		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		575416 EGR1_HUMAN (1-543): 1.51e-146: 434: 100.00		MP2K5_HUMAN (48-379): 4.35e-84: 265: 42.34
+	Hs
		1129231 ZN569_HUMAN (13-310): 2.93e-72: 245: 8.82		STK24_HUMAN (65-364): 1.58e-102: 312: 32.12
+	Hs
		1027404 ZN420_HUMAN (13-218): 1.62e-40: 157: 8.64		STK3_HUMAN (50-369): 2.6e-109: 331: 33.23
+	Hs
		1023079 ZN695_HUMAN (333-536): 6.92e-37: 145: 15.00		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		1027398 ZN695_HUMAN (333-536): 6.92e-37: 145: 15.00		STK3_HUMAN (50-369): 2.6e-109: 331: 33.23