HitPredict

Interactor 1: LRP2 (A2ARV4)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: DAB1 (P97318)
Disabled homolog 1
Gene: DAB1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.60	0.506

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005903 - brush border GO:0045177 - apical part of cell
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4660 Mm			1 588
+	Hs
		269134 LRP2_HUMAN (1-4660): 0: 3724: 76.61		DAB1_HUMAN (1-588): 1.81e-78: 260: 91.50
+	Rn
		292326 LRP2_RAT (1-4660): 0: 3822: 93.88		DAB2_RAT (8-587): 1.04e-40: 159: 25.34
+	Rn
		88518 LRP2_RAT (1-4660): 0: 3822: 93.88		ARH_RAT (8-271): 7.1e-42: 154: 16.30
+	Mm
		57558 LRP2_MOUSE (1-4660): 0: 3809: 100.00		ARH_MOUSE (8-271): 6.79e-45: 163: 16.67
+	Mm
		57554 LRP2_MOUSE (1-4660): 0: 3809: 100.00		DAB2_MOUSE (8-587): 2.89e-40: 158: 25.71
+	Hs
		957612 LRP2_HUMAN (1-4660): 0: 3724: 76.61		ARH_HUMAN (11-271): 2.37e-48: 172: 18.35
+	Hs
		957621 LRP2_HUMAN (1-4660): 0: 3724: 76.61		ANS1B_HUMAN (8-229): 3.86e-44: 171: 16.81
+	Hs
		957165 LRP2_HUMAN (1-4660): 0: 3724: 76.61		DAB2_HUMAN (8-584): 2.88e-39: 155: 25.47
+	Hs
		253552 LRP2_HUMAN (1-4660): 0: 3724: 76.61		CAPON_HUMAN (11-299): 2.87e-36: 144: 15.11
+	Mm
		956234 LRP8_MOUSE (3874-4066): 3.48e-10: 68.7: 24.23		DAB1_MOUSE (1-588): 2.98e-86: 281: 100.00
+	Hs
		269114 LDLR_HUMAN (2603-2890): 1.14e-15: 86.8: 18.90		DAB1_HUMAN (1-588): 1.81e-78: 260: 91.50
+	Hs
		269145 LRP8_HUMAN (3435-3651): 6.7e-14: 81: 22.59		DAB1_HUMAN (1-588): 1.81e-78: 260: 91.50
+	Hs
		269133 VLDLR_HUMAN (920-1116): 4.34e-10: 68.3: 17.21		DAB1_HUMAN (1-588): 1.81e-78: 260: 91.50
+	Mm
		966336 NOTC1_MOUSE (3859-4110): 7.94e-10: 67.9: 11.24		NUMB_MOUSE (4-549): 1.59e-53: 194: 15.90
+	Hs
		351073 LDLR_HUMAN (2603-2890): 1.14e-15: 86.8: 18.90		ARH_HUMAN (11-271): 2.37e-48: 172: 18.35
+	Hs
		351065 LDLR_HUMAN (2603-2890): 1.14e-15: 86.8: 18.90		DAB2_HUMAN (8-584): 2.88e-39: 155: 25.47
+	Hs
		957177 LRP8_HUMAN (3435-3651): 6.7e-14: 81: 22.59		DAB2_HUMAN (8-584): 2.88e-39: 155: 25.47
+	Hs
		253558 LRP8_HUMAN (3435-3651): 6.7e-14: 81: 22.59		CAPON_HUMAN (11-299): 2.87e-36: 144: 15.11
+	Ce
		60773 LRP_CAEEL (212-617): 7.12e-11: 71.4: 17.41		A5JYR4_CAEEL (2-386): 2.33e-36: 144: 23.06
+	Ce
		60768 O01768_CAEEL (3820-4384): 1.84e-10: 70.3: 17.09		A5JYR4_CAEEL (2-386): 2.33e-36: 144: 23.06