HitPredict

Interactor 1: LRP2 (A2ARV4)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: JIP2 (Q9ERE9)
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
Gene: Mapk8ip2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.60	0.506

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032991 - protein-containing complex GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4660 Mm			1 830
+	Hs
		957599 LRP2_HUMAN (1-4660): 0: 3724: 76.61		JIP2_HUMAN (1-830): 5.03e-144: 446: 84.51
+	Rn
		88518 LRP2_RAT (1-4660): 0: 3822: 93.88		ARH_RAT (673-815): 7.93e-35: 136: 18.62
+	Mm
		57558 LRP2_MOUSE (1-4660): 0: 3809: 100.00		ARH_MOUSE (673-815): 3.15e-37: 144: 18.62
+	Mm
		57563 LRP2_MOUSE (1-4660): 0: 3809: 100.00		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Hs
		957612 LRP2_HUMAN (1-4660): 0: 3724: 76.61		ARH_HUMAN (689-815): 4.27e-39: 149: 20.16
+	Hs
		957621 LRP2_HUMAN (1-4660): 0: 3724: 76.61		ANS1B_HUMAN (563-815): 1.75e-35: 147: 18.99
+	Hs
		957662 LRP2_HUMAN (1-4660): 0: 3724: 76.61		JIP1_HUMAN (13-349): 1.7e-13: 76.3: 22.73
+	Mm
		1266181 LRP8_MOUSE (3874-4066): 3.48e-10: 68.7: 24.23		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Mm
		69886 B1AXJ3_MOUSE (940-1144): 1.76e-09: 66.4: 15.35		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Mm
		1265299 LRP1_MOUSE (233-464): 3.78e-09: 66: 11.21		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Mm
		1322325 LRP1B_MOUSE (3825-4079): 8.05e-09: 64.9: 14.62		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Hs
		1032902 LRP8_HUMAN (3435-3651): 6.7e-14: 81: 22.59		JIP2_HUMAN (1-830): 5.03e-144: 446: 84.51
+	Hs
		992661 LRP1_HUMAN (3714-3975): 8.74e-09: 64.5: 11.36		JIP2_HUMAN (1-830): 5.03e-144: 446: 84.51
+	Hs
		351073 LDLR_HUMAN (2603-2890): 1.14e-15: 86.8: 18.90		ARH_HUMAN (689-815): 4.27e-39: 149: 20.16
+	Mm
		1257662 LRP4_MOUSE (927-1144): 2.82e-13: 79.5: 16.07		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Hs
		1048463 LRP8_HUMAN (3435-3651): 6.7e-14: 81: 22.59		JIP1_HUMAN (13-349): 1.7e-13: 76.3: 22.73
+	Mm
		1266182 LRP8_MOUSE (3874-4066): 3.48e-10: 68.7: 24.23		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Mm
		69888 B1AXJ3_MOUSE (940-1144): 1.76e-09: 66.4: 15.35		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Mm
		1265300 LRP1_MOUSE (233-464): 3.78e-09: 66: 11.21		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Mm
		1337450 LRP1B_MOUSE (3825-4079): 8.05e-09: 64.9: 14.62		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35