HitPredict

Interactor 1: LRP2 (A2ARV4)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: JIP1 (Q9WVI9)
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene: Mapk8ip1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.60	0.506

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0030424 - axon GO:0030425 - dendrite GO:0043066 - negative regulation of apoptotic process and 1 others more... GO:0044295 - axonal growth cone
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4660 Mm			1 707
+	Hs
		957662 LRP2_HUMAN (1-4660): 0: 3724: 76.61		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Mm
		57562 LRP2_MOUSE (1-4660): 0: 3809: 100.00		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Rn
		88518 LRP2_RAT (1-4660): 0: 3822: 93.88		ARH_RAT (527-692): 2.01e-34: 135: 17.54
+	Mm
		57558 LRP2_MOUSE (1-4660): 0: 3809: 100.00		ARH_MOUSE (527-692): 5.9e-37: 142: 17.54
+	Hs
		957621 LRP2_HUMAN (1-4660): 0: 3724: 76.61		ANS1B_HUMAN (419-696): 2.27e-61: 225: 18.51
+	Hs
		957599 LRP2_HUMAN (1-4660): 0: 3724: 76.61		JIP2_HUMAN (21-266): 8.52e-45: 174: 32.30
+	Hs
		253552 LRP2_HUMAN (1-4660): 0: 3724: 76.61		CAPON_HUMAN (541-703): 1.09e-36: 146: 20.69
+	Hs
		957612 LRP2_HUMAN (1-4660): 0: 3724: 76.61		ARH_HUMAN (543-702): 9.88e-38: 144: 19.14
+	Mm
		1257662 LRP4_MOUSE (927-1144): 2.82e-13: 79.5: 16.07		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Mm
		1266182 LRP8_MOUSE (3874-4066): 3.48e-10: 68.7: 24.23		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Mm
		69888 B1AXJ3_MOUSE (940-1144): 1.76e-09: 66.4: 15.35		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Hs
		1048463 LRP8_HUMAN (3435-3651): 6.7e-14: 81: 22.59		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		970699 LRP8_HUMAN (3435-3651): 6.7e-14: 81: 22.59		APBA1_HUMAN (70-698): 4.28e-126: 396: 16.54
+	Hs
		1032902 LRP8_HUMAN (3435-3651): 6.7e-14: 81: 22.59		JIP2_HUMAN (21-266): 8.52e-45: 174: 32.30
+	Mm
		1266181 LRP8_MOUSE (3874-4066): 3.48e-10: 68.7: 24.23		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Mm
		69886 B1AXJ3_MOUSE (940-1144): 1.76e-09: 66.4: 15.35		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Mm
		1265299 LRP1_MOUSE (233-464): 3.78e-09: 66: 11.21		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Hs
		351073 LDLR_HUMAN (2603-2890): 1.14e-15: 86.8: 18.90		ARH_HUMAN (543-702): 9.88e-38: 144: 19.14
+	Mm
		966336 NOTC1_MOUSE (3859-4110): 7.94e-10: 67.9: 11.24		NUMB_MOUSE (524-700): 1.37e-40: 160: 18.38
+	Hs
		253558 LRP8_HUMAN (3435-3651): 6.7e-14: 81: 22.59		CAPON_HUMAN (541-703): 1.09e-36: 146: 20.69