HitPredict

Interactor 1: SGG (P18431)
Protein kinase shaggy (EC 2.7.11.1) (Protein zeste-white 3)
Gene: SGG

Interactor 2: TNKS (Q9VBP3)
Poly [ADP-ribose] polymerase tankyrase (dTNKS) (EC 2.4.2.30) (Poly [ADP-ribose] polymerase) (Protein poly-ADP-ribosyltransferase tankyrase) (EC 2.4.2.-)
Gene: TNKS

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.820

Property	Details
Experiments	21447707, 25294943
Identification Methods	affinity chromatography technology, interactome parallel affinity capture, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:2000060 - positive regulation of ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 514 Dm			1 1181
+	Dm
		576675 SGG_DROME (1-514): 6.06e-152: 445: 100.00		Q9VMR4_DROME (276-1174): 1.61e-99: 350: 16.47
+	Dm
		65548 SGG_DROME (1-514): 6.06e-152: 445: 100.00		A8JNM5_DROME (624-1135): 9.2e-70: 260: 13.73
+	Hs
		166897 GSK3B_HUMAN (1-397): 1.68e-143: 420: 75.94		ANR28_HUMAN (14-488): 1.89e-70: 258: 24.70
+	Hs
		166896 GSK3A_HUMAN (19-419): 1.05e-137: 408: 70.57		ANR28_HUMAN (14-488): 1.89e-70: 258: 24.70
+	Hs
		960126 CDK3_HUMAN (51-355): 9.94e-139: 404: 31.63		ANFY1_HUMAN (393-1135): 7.04e-56: 214: 14.45
+	Dm
		576551 SGG_DROME (1-514): 6.06e-152: 445: 100.00		ANKHM_DROME (876-1136): 2.46e-13: 77.2: 8.81
+	Hs
		835872 GSK3B_HUMAN (1-397): 1.68e-143: 420: 75.94		ANKH1_HUMAN (828-1128): 1.85e-09: 64.5: 9.15
+	Hs
		835443 GSK3A_HUMAN (19-419): 1.05e-137: 408: 70.57		ANKH1_HUMAN (828-1128): 1.85e-09: 64.5: 9.15