HitPredict

Interactor 1: PTPRA (P18433)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
Gene: PTPRA

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 304
+	Hs
		577009 PTPRA_HUMAN (1-802): 0: 1040: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		574006 PTPRA_MOUSE (1-802): 0: 1003: 90.69		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		208991 PTPRA_HUMAN (1-802): 0: 1040: 100.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		617047 PTPRE_HUMAN (130-802): 0: 836: 66.81		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		146925 PTPRT_HUMAN (51-795): 0: 778: 31.14		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		663965 PTN4_HUMAN (515-793): 2.43e-103: 341: 33.80		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		663966 PTN4_HUMAN (515-793): 2.43e-103: 341: 33.80		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		548649 PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		580992 PTPRJ_HUMAN (516-797): 1.76e-118: 390: 38.87		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		924529 PTPRJ_HUMAN (516-797): 1.76e-118: 390: 38.87		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		580938 PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		562628 PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		665853 PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		663972 PTN4_HUMAN (515-793): 2.43e-103: 341: 33.80		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		420370 PTPRC_MOUSE (207-530): 2.75e-72: 259: 27.48		VAV_MOUSE (11-189): 7.04e-46: 167: 27.23
+	Hs
		557617 PTN4_HUMAN (515-793): 2.43e-103: 341: 33.80		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Mm
		420374 PTPRC_MOUSE (207-530): 2.75e-72: 259: 27.48		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67