HitPredict

Interactor 1: PTPRA (P18433)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
Gene: PTPRA

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.988

Property	Details
Experiments	27880917, 28514442, 23532252, 8670803, 32062451, 33961781, 24189400, 31980649, 7518772, 11923305, 35271311, 19380743, 28330616, 28065597, unassigned2173
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, ubiquitin reconstruction, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0008286 - insulin receptor signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 217
+	Mm
		574006 PTPRA_MOUSE (1-802): 0: 1003: 90.69		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		411997 PTPRA_HUMAN (1-802): 0: 1040: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		522756 PTPRA_HUMAN (1-802): 0: 1040: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Rn
		1144045 Q66HJ7_RAT (1-802): 0: 1018: 94.16		FYN_RAT (161-215): 4.44e-14: 72.3: 31.58
+	Rn
		1146020 Q66HJ7_RAT (1-802): 0: 1018: 94.16		SRC_RAT (117-215): 2.55e-11: 64.2: 20.79
+	Mm
		574000 PTPRA_MOUSE (1-802): 0: 1003: 90.69		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Mm
		403413 PTPRA_MOUSE (1-802): 0: 1003: 90.69		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Rn
		976063 PTPRA_RAT (1-802): 0: 1002: 93.04		SRC_RAT (117-215): 2.55e-11: 64.2: 20.79
+	Hs
		617047 PTPRE_HUMAN (130-802): 0: 836: 66.81		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411565 PTPRF_HUMAN (4-799): 0: 894: 40.52		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Mm
		56907 PTPRF_MOUSE (4-799): 0: 905: 40.52		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		412016 PTPRD_HUMAN (38-799): 0: 897: 40.50		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		411959 PTPRF_HUMAN (4-799): 0: 894: 40.52		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Dm
		337644 LAR_DROME (44-800): 0: 851: 40.00		ABL_DROME (4-135): 1e-22: 97.4: 37.68
+	Hs
		411597 PTPRG_HUMAN (14-798): 0: 788: 29.12		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		412017 PTPRE_HUMAN (130-802): 0: 836: 66.81		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433255 PTPRE_HUMAN (130-802): 0: 836: 66.81		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		617084 PTPRG_HUMAN (14-798): 0: 788: 29.12		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Rn
		94284 F1LXJ9_RAT (48-795): 0: 784: 31.67		FYN_RAT (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433579 PTPRG_HUMAN (14-798): 0: 788: 29.12		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47