HitPredict

Interactor 1: PTPRA (P18433)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
Gene: PTPRA

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 509
+	Hs
		576989 PTPRA_HUMAN (1-802): 0: 1040: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		208991 PTPRA_HUMAN (1-802): 0: 1040: 100.00		NCK2_HUMAN (157-505): 7.36e-63: 211: 17.45
+	Hs
		522756 PTPRA_HUMAN (1-802): 0: 1040: 100.00		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Rn
		1146020 Q66HJ7_RAT (1-802): 0: 1018: 94.16		SRC_RAT (264-488): 6e-63: 216: 17.30
+	Hs
		411997 PTPRA_HUMAN (1-802): 0: 1040: 100.00		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Mm
		403413 PTPRA_MOUSE (1-802): 0: 1003: 90.69		SRC_MOUSE (264-488): 1.12e-63: 218: 18.64
+	Rn
		976063 PTPRA_RAT (1-802): 0: 1002: 93.04		SRC_RAT (264-488): 6e-63: 216: 17.30
+	Rn
		1144045 Q66HJ7_RAT (1-802): 0: 1018: 94.16		FYN_RAT (283-506): 1.94e-53: 190: 15.16
+	Hs
		577009 PTPRA_HUMAN (1-802): 0: 1040: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Mm
		574000 PTPRA_MOUSE (1-802): 0: 1003: 90.69		FYN_MOUSE (283-506): 1.94e-53: 190: 15.16
+	Mm
		56907 PTPRF_MOUSE (4-799): 0: 905: 40.52		FYN_MOUSE (283-506): 1.94e-53: 190: 15.16
+	Hs
		412016 PTPRD_HUMAN (38-799): 0: 897: 40.50		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		411959 PTPRF_HUMAN (4-799): 0: 894: 40.52		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		617042 PTPRE_HUMAN (130-802): 0: 836: 66.81		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Mm
		828096 PTPRE_MOUSE (107-802): 0: 827: 65.05		SHC1_MOUSE (105-508): 5.58e-66: 225: 17.12
+	Dm
		337644 LAR_DROME (44-800): 0: 851: 40.00		ABL_DROME (332-507): 3.08e-50: 187: 26.55
+	Hs
		433255 PTPRE_HUMAN (130-802): 0: 836: 66.81		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		412017 PTPRE_HUMAN (130-802): 0: 836: 66.81		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		617047 PTPRE_HUMAN (130-802): 0: 836: 66.81		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Rn
		94284 F1LXJ9_RAT (48-795): 0: 784: 31.67		FYN_RAT (283-506): 1.94e-53: 190: 15.16