HitPredict

Interactor 1: EMS (P18488)
Homeotic protein empty spiracles
Gene: EMS

Interactor 2: UBX (P83949)
Homeotic protein ultrabithorax
Gene: UBX

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25869471, 30247122
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0007424 - open tracheal system development
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 497 Dm			1 389
+	Dm
		950014 Q7KS72_DROME (315-465): 1.18e-37: 142: 31.61		UBX_DROME (1-389): 3.26e-124: 365: 100.00
+	Dm
		950100 Q9W1H7_DROME (360-497): 3.93e-32: 124: 18.84		UBX_DROME (1-389): 3.26e-124: 365: 100.00
+	Dm
		577200 EMS_DROME (1-497): 3.92e-57: 199: 100.00		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Dm
		447314 EMS_DROME (1-497): 3.92e-57: 199: 100.00		SCR_DROME (289-353): 5.65e-24: 104: 80.00
+	Dm
		668261 Q7KS72_DROME (315-465): 1.18e-37: 142: 31.61		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Hs
		679073 TLX1_HUMAN (334-465): 4.86e-29: 118: 34.06		MNX1_HUMAN (197-387): 6.03e-52: 179: 33.67
+	Dm
		668312 Q9W1H7_DROME (360-497): 3.93e-32: 124: 18.84		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Dm
		1365624 Q9VFQ3_DROME (353-463): 7.07e-40: 153: 76.58		Q9W1H7_DROME (289-389): 6.72e-34: 127: 29.81
+	Hs
		211793 HXB9_HUMAN (180-456): 1.54e-40: 148: 24.20		TLX3_HUMAN (118-388): 1.09e-31: 123: 17.34
+	Hs
		837783 MEOX1_HUMAN (229-474): 3.4e-35: 133: 23.26		MEOX2_HUMAN (114-366): 8.49e-34: 129: 20.16
+	Hs
		678889 MEOX1_HUMAN (229-474): 3.4e-35: 133: 23.26		HXC8_HUMAN (146-363): 3.56e-32: 123: 31.65
+	Hs
		446864 HXA5_HUMAN (280-460): 1.55e-29: 118: 24.47		HXD4_HUMAN (144-389): 1.64e-36: 135: 26.02
+	Ce
		712513 Q19937_CAEEL (345-474): 1.41e-30: 119: 31.79		LIN39_CAEEL (154-357): 7.85e-34: 128: 30.09
+	Hs
		453052 HXA7_HUMAN (266-463): 1.79e-30: 120: 19.40		HXB7_HUMAN (139-364): 7.88e-33: 124: 31.86
+	Hs
		453048 HXB7_HUMAN (254-461): 2.26e-30: 119: 19.14		HXA5_HUMAN (120-367): 8.65e-32: 123: 31.73
+	Hs
		567821 HXA1_HUMAN (213-464): 2.2e-29: 119: 21.65		HXB9_HUMAN (141-360): 6.75e-32: 122: 23.68
+	Hs
		567816 TLX1_HUMAN (334-465): 4.86e-29: 118: 34.06		HXB9_HUMAN (141-360): 6.75e-32: 122: 23.68
+	Dm
		447327 HMPB_DROME (352-472): 5.99e-30: 126: 33.86		SCR_DROME (289-353): 5.65e-24: 104: 80.00