HitPredict

Interactor 1: SYB (P18489)
Synaptobrevin
Gene: SYB

Interactor 2: Q7JYX5 (Q7JYX5)
Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1)
Gene: Vamp7

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Longin~Synaptobrevin, Synaptobrevin~Synaptobrevin
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0006906 - vesicle fusion GO:0019905 - syntaxin binding GO:0031201 - SNARE complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 152 Dm			1 218
+	Hs
		850543 VAMP7_HUMAN (23-112): 1.58e-29: 108: 26.09		VAMP7_HUMAN (1-218): 2.8e-84: 250: 52.29
+	Dm
		115796 SYB_DROME (1-152): 8.51e-56: 173: 100.00		M9PGI6_DROME (24-206): 1.15e-56: 180: 25.54
+	Hs
		850567 VAMP3_HUMAN (34-114): 7.67e-28: 100: 61.73		VAMP7_HUMAN (1-218): 2.8e-84: 250: 52.29
+	Dm
		577266 SYB_DROME (1-152): 8.51e-56: 173: 100.00		Q9W3M8_DROME (5-179): 3.75e-50: 163: 22.16
+	Hs
		306775 VAMP5_HUMAN (44-114): 5.1e-19: 79: 40.85		VAMP7_HUMAN (1-218): 2.8e-84: 250: 52.29
+	Dm
		115809 Q7JYX5_DROME (23-127): 1.45e-36: 126: 16.82		M9PGI6_DROME (24-206): 1.15e-56: 180: 25.54
+	Dm
		1178144 Q7JYX5_DROME (23-127): 1.45e-36: 126: 16.82		Q9W3M8_DROME (5-179): 3.75e-50: 163: 22.16
+	Sc
		605815 SEC22_YEAST (3-129): 2.65e-33: 118: 19.38		SEC22_YEAST (37-206): 9.08e-51: 165: 21.64
+	Sc
		605836 SEC22_YEAST (3-129): 2.65e-33: 118: 19.38		YKT6_YEAST (5-179): 3.91e-51: 165: 21.02
+	Hs
		263123 VAMP5_HUMAN (44-114): 5.1e-19: 79: 40.85		SC22B_HUMAN (23-206): 2.46e-64: 200: 20.54
+	Dm
		115851 M9PGI6_DROME (3-128): 1.23e-31: 113: 16.67		Q9W3M8_DROME (5-179): 3.75e-50: 163: 22.16
+	Sc
		605833 SNC2_YEAST (18-115): 6.95e-29: 103: 29.59		SEC22_YEAST (37-206): 9.08e-51: 165: 21.64
+	Hs
		180776 VAMP5_HUMAN (44-114): 5.1e-19: 79: 40.85		YKT6_HUMAN (22-179): 6.23e-54: 173: 27.67
+	Sc
		605883 NYV1_YEAST (37-123): 2.46e-18: 80.1: 24.18		SEC22_YEAST (37-206): 9.08e-51: 165: 21.64
+	Sc
		731090 NYV1_YEAST (37-123): 2.46e-18: 80.1: 24.18		YKT6_YEAST (5-179): 3.91e-51: 165: 21.02
+	Hs
		1079421 VAMP3_HUMAN (34-114): 7.67e-28: 100: 61.73		VAMP8_HUMAN (124-193): 2.6e-11: 60.1: 35.71
+	Hs
		926250 VAMP2_HUMAN (41-130): 1.98e-27: 100: 68.89		VAMP8_HUMAN (124-193): 2.6e-11: 60.1: 35.71
+	Hs
		306857 VAMP5_HUMAN (44-114): 5.1e-19: 79: 40.85		VAMP8_HUMAN (124-193): 2.6e-11: 60.1: 35.71