Interactor 1: PTC (P18502)
Protein patched (Hedgehog receptor)
Gene: PTC

Interactor 2: SMUF1 (Q9V853)
E3 ubiquitin-protein ligase Smurf1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Smurf1) (Lethal with a checkpoint kinase protein) (SMAD ubiquitination regulatory factor 1 homolog) (DSmurf)
Gene: Smurf

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 0.60 0.620

The method score is based on:

Property Details
Experiments 24302888, 29438012
Identification Methods affinity chromatography technology, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0045879 - negative regulation of smoothened signaling pathway
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 1286
Dm

1 1061
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Last updated: 15 Jul 2024