HitPredict

Interactor 1: PTC (P18502)
Protein patched (Hedgehog receptor)
Gene: PTC

Interactor 2: GZL (Q9VI20)
E3 ubiquitin-protein ligase Godzilla (EC 2.3.2.27)
Gene: GZL

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.439

Property	Details
Experiments	15710747
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1286 Dm			1 536
+	Dm
		577370 PTC_DROME (1-1286): 0: 1295: 100.00		HRD1_DROME (110-336): 7.05e-33: 134: 16.09
+	Hs
		1044374 PTC1_HUMAN (24-1261): 0: 1165: 37.25		GOLI_HUMAN (21-369): 5.94e-60: 205: 21.02
+	Hs
		230138 PTC1_HUMAN (24-1261): 0: 1165: 37.25		MGRN1_HUMAN (222-507): 7.54e-33: 134: 17.35
+	Hs
		167772 NPC1_HUMAN (59-1111): 0: 736: 18.69		RNF13_HUMAN (30-351): 7.9e-72: 235: 34.86
+	Hs
		167957 NPC1_HUMAN (59-1111): 0: 736: 18.69		SYVN1_HUMAN (110-519): 7.47e-45: 169: 13.09
+	Hs
		168073 NPC1_HUMAN (59-1111): 0: 736: 18.69		AMFR_HUMAN (147-497): 4.05e-34: 138: 13.37
+	Hs
		1262022 DISP1_HUMAN (339-1193): 8.1e-154: 504: 14.46		RN133_HUMAN (6-352): 3.98e-75: 244: 18.46
+	Hs
		1016006 SCAP_HUMAN (317-783): 2.79e-62: 235: 13.21		ZNRF4_HUMAN (3-352): 2.29e-57: 199: 25.14
+	Hs
		373137 HMDH_HUMAN (427-774): 2.14e-49: 192: 12.54		RN148_HUMAN (19-283): 7.85e-66: 217: 20.22
+	Hs
		373142 HMDH_HUMAN (427-774): 2.14e-49: 192: 12.54		ZNRF4_HUMAN (3-352): 2.29e-57: 199: 25.14
+	Hs
		373130 HMDH_HUMAN (427-774): 2.14e-49: 192: 12.54		SYVN1_HUMAN (110-519): 7.47e-45: 169: 13.09
+	Hs
		373164 HMDH_HUMAN (427-774): 2.14e-49: 192: 12.54		AMFR_HUMAN (147-497): 4.05e-34: 138: 13.37
+	Dm
		51415 A1Z6J2_DROME (312-692): 9.16e-63: 237: 13.03		Q8SX72_DROME (210-277): 1.16e-09: 63.2: 41.18