Interactor 1: RCC1 (P18754)
Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)
Gene: RCC1

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 26186194, 29997244, 10811801, 11336674, 7891706, 37071682, 20565941, 28514442, 10369786, 33961781, 35271311, 7988569, 10827954, unassigned1913, 1961752, 18617507
Identification Methods affinity chromatography technology, pull down, x-ray crystallography, two hybrid, cross-linking study, luminescence based mammalian interactome mapping, split luciferase complementation, mammalian protein protein interaction trap, comigration in gel electrophoresis, anti bait coimmunoprecipitation and 1 others

more...

Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains RCC1~Ras
Common GO terms GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 5 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 421
Hs

1 216
+ Mm
+ Hs
+ Sp
+ Sc
+ Sc
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024