HitPredict

Interactor 1: KALRN (A2CG49)
Kalirin (EC 2.7.11.1) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)
Gene: KALRN

Interactor 2: GIT1 (Q68FF6)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1)
Gene: GIT1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28706196
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~fn3, Ank_2~I-set, ArfGap~PH, Ank_2~Pkinase, Ank_2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0014069 - postsynaptic density GO:0046872 - metal ion binding GO:0098978 - glutamatergic synapse GO:0099645 - neurotransmitter receptor localization to postsynaptic specialization membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2964 Mm			1 770
+	Mm
		57849 KALRN_MOUSE (1-2964): 0: 2415: 100.00		Q5F258_MOUSE (1-770): 1.89e-162: 490: 98.57
+	Mm
		57843 KALRN_MOUSE (1-2964): 0: 2415: 100.00		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Mm
		57869 KALRN_MOUSE (1-2964): 0: 2415: 100.00		ANK2_MOUSE (89-573): 7.21e-30: 129: 11.89
+	Mm
		1002014 TRIO_MOUSE (4-2954): 0: 2079: 60.05		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Hs
		1164348 ARHGP_HUMAN (1231-1656): 1.1e-122: 403: 31.22		POTEE_HUMAN (52-620): 2.12e-39: 159: 12.41
+	Mm
		82757 B9EKJ1_MOUSE (123-1917): 1.7e-90: 333: 12.03		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Mm
		561159 SPTN1_MOUSE (123-1985): 8.08e-90: 330: 11.90		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Mm
		1112587 Q68FG2_MOUSE (15-1589): 3.07e-87: 322: 12.35		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Mm
		1112582 SPTB2_MOUSE (83-1591): 9.52e-85: 313: 12.83		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Mm
		82740 B9EKJ1_MOUSE (123-1917): 1.7e-90: 333: 12.03		ANK3_MOUSE (60-565): 6.42e-37: 152: 12.73
+	Hs
		1021399 SPTN1_HUMAN (123-1917): 6.62e-91: 334: 11.84		ANK3_HUMAN (174-528): 8.05e-33: 139: 10.36
+	Hs
		963306 SPTB2_HUMAN (26-1251): 3.09e-89: 328: 13.35		ANK3_HUMAN (174-528): 8.05e-33: 139: 10.36
+	Hs
		965102 SPTN1_HUMAN (123-1917): 6.62e-91: 334: 11.84		ANK2_HUMAN (89-573): 7.15e-31: 133: 11.72
+	Mm
		103603 SPTB2_MOUSE (83-1591): 9.52e-85: 313: 12.83		ANK3_MOUSE (60-565): 6.42e-37: 152: 12.73
+	Hs
		963292 SPTB2_HUMAN (26-1251): 3.09e-89: 328: 13.35		ANK2_HUMAN (89-573): 7.15e-31: 133: 11.72
+	Mm
		561172 SPTN1_MOUSE (123-1985): 8.08e-90: 330: 11.90		ANK2_MOUSE (89-573): 7.21e-30: 129: 11.89
+	Hs
		164611 SPTN2_HUMAN (15-1276): 9.58e-86: 317: 12.99		ANK3_HUMAN (174-528): 8.05e-33: 139: 10.36
+	Mm
		103598 Q3UGX2_MOUSE (42-1174): 2.69e-80: 299: 13.70		ANK3_MOUSE (60-565): 6.42e-37: 152: 12.73
+	Hs
		164604 SPTN2_HUMAN (15-1276): 9.58e-86: 317: 12.99		ANK2_HUMAN (89-573): 7.15e-31: 133: 11.72
+	Hs
		556695 SPTB2_HUMAN (26-1251): 3.09e-89: 328: 13.35		ANK1_HUMAN (225-526): 1.12e-09: 64.5: 10.39