HitPredict

Interactor 1: KALRN (A2CG49)
Kalirin (EC 2.7.11.1) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)
Gene: KALRN

Interactor 2: ANK2 (Q8C8R3)
Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin)
Gene: ANK2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28706196
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~fn3, Ank~I-set, Ank_2~I-set, Ank~Pkinase, Ank_2~Pkinase, Ank_4~Pkinase, Ank_2~SH3_1, Spectrin~UPA_2, Spectrin~ZU5
Common GO terms	GO:0005737 - cytoplasm GO:0005856 - cytoskeleton GO:0014069 - postsynaptic density GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2964 Mm			1 3898
+	Hs
		279899 TRIO_HUMAN (4-2954): 0: 2090: 59.95		ANFY1_HUMAN (467-1255): 4.46e-99: 351: 16.82
+	Mm
		561172 SPTN1_MOUSE (123-1985): 8.08e-90: 330: 11.90		ANK2_MOUSE (1-3898): 0: 1753: 100.00
+	Hs
		965102 SPTN1_HUMAN (123-1917): 6.62e-91: 334: 11.84		ANK2_HUMAN (1-3898): 0: 1678: 80.49
+	Hs
		963292 SPTB2_HUMAN (26-1251): 3.09e-89: 328: 13.35		ANK2_HUMAN (1-3898): 0: 1678: 80.49
+	Hs
		164604 SPTN2_HUMAN (15-1276): 9.58e-86: 317: 12.99		ANK2_HUMAN (1-3898): 0: 1678: 80.49
+	Hs
		965118 OBSCN_HUMAN (2228-2940): 1.25e-62: 242: 21.94		ANK2_HUMAN (1-3898): 0: 1678: 80.49
+	Hs
		862028 DAPK1_HUMAN (2645-2914): 4.78e-62: 238: 41.37		ANK2_HUMAN (1-3898): 0: 1678: 80.49
+	Hs
		556695 SPTB2_HUMAN (26-1251): 3.09e-89: 328: 13.35		ANK1_HUMAN (2-747): 0: 761: 33.73
+	Hs
		556706 OBSCN_HUMAN (2228-2940): 1.25e-62: 242: 21.94		ANK1_HUMAN (2-747): 0: 761: 33.73
+	Hs
		360612 SPTA1_HUMAN (161-886): 1.78e-48: 194: 15.52		ANK1_HUMAN (2-747): 0: 761: 33.73
+	Hs
		506803 SPTB1_HUMAN (9-825): 3.12e-43: 177: 14.30		ANK1_HUMAN (2-747): 0: 761: 33.73
+	Hs
		556716 TITIN_HUMAN (2335-2541): 1.3e-09: 66.8: 20.29		ANK1_HUMAN (2-747): 0: 761: 33.73
+	Mm
		82740 B9EKJ1_MOUSE (123-1917): 1.7e-90: 333: 12.03		ANK3_MOUSE (1070-1252): 1.01e-12: 77.3: 10.93
+	Hs
		1021399 SPTN1_HUMAN (123-1917): 6.62e-91: 334: 11.84		ANK3_HUMAN (1021-1261): 3.23e-10: 69.2: 12.10
+	Hs
		963306 SPTB2_HUMAN (26-1251): 3.09e-89: 328: 13.35		ANK3_HUMAN (1021-1261): 3.23e-10: 69.2: 12.10
+	Mm
		103603 SPTB2_MOUSE (83-1591): 9.52e-85: 313: 12.83		ANK3_MOUSE (1070-1252): 1.01e-12: 77.3: 10.93
+	Hs
		164611 SPTN2_HUMAN (15-1276): 9.58e-86: 317: 12.99		ANK3_HUMAN (1021-1261): 3.23e-10: 69.2: 12.10
+	Mm
		103598 Q3UGX2_MOUSE (42-1174): 2.69e-80: 299: 13.70		ANK3_MOUSE (1070-1252): 1.01e-12: 77.3: 10.93
+	Hs
		1021458 SPTN4_HUMAN (46-1276): 5.46e-73: 275: 14.00		ANK3_HUMAN (1021-1261): 3.23e-10: 69.2: 12.10
+	Hs
		166985 TITIN_HUMAN (2335-2541): 1.3e-09: 66.8: 20.29		ANR28_HUMAN (1087-1253): 3.37e-15: 85: 9.58