HitPredict

Interactor 1: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Interactor 2: TPM4 (P67936)
Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)
Gene: TPM4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30833792
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042803 - protein homodimerization activity GO:0046982 - protein heterodimerization activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 181 Hs			1 248
+	Hs
		345288 FOS_HUMAN (14-158): 2.36e-25: 102: 26.25		TPM1_HUMAN (4-248): 1.43e-48: 163: 68.16
+	Hs
		451186 ATF2_HUMAN (17-162): 6.51e-25: 101: 21.92		TPM1_HUMAN (4-248): 1.43e-48: 163: 68.16
+	Hs
		3155 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		A0A0S2Z4G4_HUMAN (1-248): 8.76e-50: 165: 75.81
+	Hs
		345283 FOS_HUMAN (14-158): 2.36e-25: 102: 26.25		TPM3_HUMAN (4-248): 6.47e-47: 159: 69.39
+	Hs
		418870 JUNB_HUMAN (27-155): 8.92e-26: 102: 18.46		TPM3_HUMAN (4-248): 6.47e-47: 159: 69.39
+	Hs
		345393 FOS_HUMAN (14-158): 2.36e-25: 102: 26.25		TPM4_HUMAN (1-248): 5.49e-47: 158: 100.00
+	Hs
		418865 ATF2_HUMAN (17-162): 6.51e-25: 101: 21.92		TPM3_HUMAN (4-248): 6.47e-47: 159: 69.39
+	Hs
		401292 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		TPM1_HUMAN (4-248): 1.43e-48: 163: 68.16
+	Mm
		404129 JUN_MOUSE (10-155): 1.94e-23: 96.5: 19.46		TPM1_MOUSE (4-248): 1.11e-48: 163: 68.57
+	Hs
		547777 ATF2_HUMAN (17-162): 6.51e-25: 101: 21.92		TPM4_HUMAN (1-248): 5.49e-47: 158: 100.00
+	Hs
		401268 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		TPM3_HUMAN (4-248): 6.47e-47: 159: 69.39
+	Hs
		451187 JUND_HUMAN (53-158): 7.76e-22: 92.2: 24.30		TPM1_HUMAN (4-248): 1.43e-48: 163: 68.16
+	Hs
		418871 JUND_HUMAN (53-158): 7.76e-22: 92.2: 24.30		TPM3_HUMAN (4-248): 6.47e-47: 159: 69.39
+	Mm
		404130 JUN_MOUSE (10-155): 1.94e-23: 96.5: 19.46		TPM2_MOUSE (4-248): 5.85e-42: 146: 69.39
+	Dm
		419095 JRA_DROME (13-159): 1.51e-21: 90.3: 19.60		TPM1_DROME (7-241): 5.05e-09: 57.7: 24.68