HitPredict

Interactor 1: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Interactor 2: HDA10 (Q969S8)
Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10)
Gene: HDAC10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22989952
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Hs			1 669
+	Hs
		1264524 JDP2_HUMAN (73-176): 1.03e-20: 85.7: 59.62		HDA10_HUMAN (1-669): 0: 866: 100.00
+	Hs
		579204 ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00		HDAC1_HUMAN (6-449): 1.69e-153: 454: 20.09
+	Mm
		936396 ATF3_MOUSE (1-181): 6.94e-41: 137: 95.03		HDAC2_MOUSE (6-457): 1.39e-151: 449: 19.96
+	Hs
		579232 ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00		HDAC6_HUMAN (3-409): 1.45e-141: 445: 47.55
+	Mm
		140216 JUNB_MOUSE (10-155): 8.33e-28: 108: 18.37		HDAC1_MOUSE (6-449): 4.86e-154: 455: 20.09
+	Mm
		450547 JUNB_MOUSE (10-155): 8.33e-28: 108: 18.37		HDAC2_MOUSE (6-457): 1.39e-151: 449: 19.96
+	Hs
		345504 FOS_HUMAN (14-158): 2.36e-25: 102: 26.25		HDAC2_HUMAN (6-457): 3.88e-152: 451: 19.96
+	Dm
		599218 FOSLA_DROME (4-163): 3.4e-27: 108: 23.13		HDAC1_DROME (6-459): 2.75e-149: 444: 18.78
+	Hs
		401956 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		HDAC1_HUMAN (6-449): 1.69e-153: 454: 20.09
+	Hs
		402302 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		HDAC2_HUMAN (6-457): 3.88e-152: 451: 19.96
+	Hs
		548245 FOSL1_HUMAN (42-169): 1.11e-22: 93.4: 26.76		HDAC1_HUMAN (6-449): 1.69e-153: 454: 20.09
+	Hs
		1038579 JDP2_HUMAN (73-176): 1.03e-20: 85.7: 59.62		HDAC1_HUMAN (6-449): 1.69e-153: 454: 20.09
+	Mm
		526735 FOSB_MOUSE (96-163): 9.36e-20: 86.4: 45.59		HDAC2_MOUSE (6-457): 1.39e-151: 449: 19.96
+	Dm
		576068 JRA_DROME (13-159): 1.51e-21: 90.3: 19.60		HDAC1_DROME (6-459): 2.75e-149: 444: 18.78
+	Hs
		579236 ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00		HDAC5_HUMAN (434-663): 1.83e-25: 114: 19.79
+	Hs
		579186 ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00		HDAC4_HUMAN (434-663): 6.76e-24: 109: 18.38
+	Sp
		857023 ATF1_SCHPO (7-171): 3.47e-26: 105: 20.48		CLR3_SCHPO (321-662): 6.79e-33: 136: 16.82
+	Hs
		547761 ATF2_HUMAN (17-162): 6.51e-25: 101: 21.92		HDAC4_HUMAN (434-663): 6.76e-24: 109: 18.38
+	Hs
		402607 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		HDAC9_HUMAN (439-657): 2.79e-24: 110: 18.38
+	Hs
		880797 JDP2_HUMAN (73-176): 1.03e-20: 85.7: 59.62		HDAC4_HUMAN (434-663): 6.76e-24: 109: 18.38