Interactor 1: XRCC1 (P18887)
DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)
Gene: XRCC1
Interactor 2: PNKP (Q96T60)
Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]
Gene: PNKP
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 0.60 | 0.755 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26496610, 11163244, 17353931, 34111398, 28821613, 15367657, 15385968, 19155274, 21637298 |
| Identification Methods | affinity chromatography technology, two hybrid, pull down, far western blotting, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, x-ray crystallography, isothermal titration calorimetry |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0006303 - double-strand break repair via nonhomologous end joining GO:0010836 - negative regulation of protein ADP-ribosylation |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
