HitPredict

Interactor 1: K2C4 (P19013)
Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4)
Gene: KRT4

Interactor 2: EPIPL (P58107)
Epiplakin (450 kDa epidermal antigen)
Gene: EPPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045095 - keratin filament GO:0045109 - intermediate filament organization GO:0045111 - intermediate filament cytoskeleton GO:0050680 - negative regulation of epithelial cell proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 520 Hs			1 5088
+	Hs
		517744 K2C3_HUMAN (109-492): 1.48e-160: 471: 72.24		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		409039 K2C8_HUMAN (109-484): 5.4e-161: 467: 62.50		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		444531 K2C7_HUMAN (94-464): 5.39e-147: 431: 66.04		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885274 K2C78_HUMAN (71-481): 5.46e-140: 415: 60.38		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885269 K2C73_HUMAN (2-453): 6.11e-100: 313: 63.74		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		318791 K2C75_HUMAN (2-464): 3.36e-94: 298: 64.29		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		213934 KRT86_HUMAN (10-520): 1.16e-90: 287: 45.22		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885251 K2C72_HUMAN (2-453): 6.1e-82: 265: 63.22		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885248 K1H2_HUMAN (39-450): 1.41e-66: 223: 23.30		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		409080 K2C8_HUMAN (109-484): 5.4e-161: 467: 62.50		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		1068595 K2C78_HUMAN (71-481): 5.46e-140: 415: 60.38		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		380553 K2C1_HUMAN (102-468): 1.76e-159: 469: 69.21		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		408995 K2C8_HUMAN (109-484): 5.4e-161: 467: 62.50		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		234174 K2C8_HUMAN (109-484): 5.4e-161: 467: 62.50		PEPL_HUMAN (2575-3932): 2.76e-26: 122: 10.40
+	Hs
		409163 K2C8_HUMAN (109-484): 5.4e-161: 467: 62.50		NIN_HUMAN (2307-3806): 1.16e-14: 84: 9.19
+	Hs
		821662 K2C6C_HUMAN (1-469): 8.67e-79: 258: 62.63		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		408985 K2C8_HUMAN (109-484): 5.4e-161: 467: 62.50		DMD_HUMAN (1909-3327): 6.13e-09: 65.1: 11.08
+	Hs
		531529 K2C5_HUMAN (2-453): 1.82e-78: 258: 65.91		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		359462 K2C6A_HUMAN (33-469): 4.72e-75: 249: 67.05		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		531604 K2C5_HUMAN (2-453): 1.82e-78: 258: 65.91		NIN_HUMAN (2307-3806): 1.16e-14: 84: 9.19