HitPredict

Interactor 1: K2C4 (P19013)
Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4)
Gene: KRT4

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25604459
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 520 Hs			1 530
+	Hs
		369912 K2C1B_HUMAN (47-468): 4.52e-166: 484: 61.86		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368794 K2C1_HUMAN (102-468): 1.76e-159: 469: 69.21		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368816 K2C8_HUMAN (109-484): 5.4e-161: 467: 62.50		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1231024 K2C78_HUMAN (71-481): 5.46e-140: 415: 60.38		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369983 K2C78_HUMAN (71-481): 5.46e-140: 415: 60.38		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		611385 K22E_HUMAN (109-490): 3.71e-151: 448: 65.71		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		318855 K2C75_HUMAN (2-464): 3.36e-94: 298: 64.29		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		943688 KRT85_HUMAN (4-511): 5.37e-93: 294: 46.76		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		213976 KRT86_HUMAN (10-520): 1.16e-90: 287: 45.22		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1062061 K2C72_HUMAN (2-453): 6.1e-82: 265: 63.22		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369795 K2C79_HUMAN (2-468): 3.78e-85: 274: 62.82		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		280820 KRT36_HUMAN (2-450): 9.17e-67: 224: 25.39		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368958 K2C4_HUMAN (1-520): 1.79e-83: 270: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370133 KRT35_HUMAN (39-450): 6.77e-68: 227: 25.49		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		487082 K2C3_HUMAN (109-492): 1.48e-160: 471: 72.24		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		408982 K2C8_HUMAN (109-484): 5.4e-161: 467: 62.50		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59