HitPredict

Interactor 1: CADH2 (P19022)
Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)
Gene: CDH2

Interactor 2: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005911 - cell-cell junction GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 595
+	Hs
		580200 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85
+	Hs
		580234 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86
+	Hs
		580229 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRJ_HUMAN (234-549): 8.15e-115: 373: 33.12
+	Hs
		580269 CADH2_HUMAN (1-906): 0: 998: 100.00		PTN22_HUMAN (227-574): 2.23e-118: 371: 31.02
+	Rn
		1145482 CADH2_RAT (1-906): 0: 989: 96.25		PTPRF_RAT (93-516): 5.83e-113: 372: 26.76
+	Hs
		576981 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRA_HUMAN (125-516): 8.95e-108: 343: 27.38
+	Hs
		441173 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRC_HUMAN (118-575): 2.27e-82: 283: 20.20
+	Hs
		580235 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06
+	Rn
		94056 CADH2_RAT (1-906): 0: 989: 96.25		F1LPJ1_RAT (72-519): 8.7e-73: 256: 20.64
+	Hs
		580201 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRG_HUMAN (130-547): 4.44e-60: 218: 20.14
+	Hs
		580226 CADH2_HUMAN (1-906): 0: 998: 100.00		PTN12_HUMAN (253-530): 7.2e-50: 186: 39.43
+	Hs
		521713 CADH1_HUMAN (26-906): 0: 764: 45.71		PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86
+	Hs
		521727 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41
+	Hs
		521907 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRS_HUMAN (108-516): 3.34e-114: 376: 27.93
+	Hs
		521898 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRJ_HUMAN (234-549): 8.15e-115: 373: 33.12
+	Hs
		489891 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRF_HUMAN (93-516): 1.07e-112: 372: 26.98
+	Hs
		616974 DSC3_HUMAN (5-899): 0: 700: 30.32		PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41
+	Hs
		521743 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRM_HUMAN (59-519): 1.46e-72: 255: 20.78
+	Mm
		454946 CADH1_MOUSE (2-906): 0: 743: 45.13		PTPRM_MOUSE (59-519): 7.12e-73: 256: 20.78
+	Hs
		521728 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRG_HUMAN (130-547): 4.44e-60: 218: 20.14