HitPredict

Interactor 1: CADH2 (P19022)
Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)
Gene: CDH2

Interactor 2: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21875946
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007416 - synapse assembly GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 607
+	Hs
		507842 CADH2_HUMAN (1-906): 0: 998: 100.00		FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29
+	Hs
		580237 CADH2_HUMAN (1-906): 0: 998: 100.00		NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92
+	Hs
		384238 CADH2_HUMAN (1-906): 0: 998: 100.00		NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65
+	Hs
		441427 CADH2_HUMAN (1-906): 0: 998: 100.00		MET_HUMAN (265-593): 1.87e-59: 217: 35.95
+	Hs
		507817 CADH1_HUMAN (26-906): 0: 764: 45.71		FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29
+	Hs
		580227 CADH2_HUMAN (1-906): 0: 998: 100.00		TYRO3_HUMAN (315-592): 1.89e-53: 198: 37.50
+	Hs
		435531 CADH2_HUMAN (1-906): 0: 998: 100.00		IGF1R_HUMAN (325-598): 2.72e-50: 189: 34.42
+	Hs
		713786 DSC2_HUMAN (42-899): 0: 710: 30.46		RYK_HUMAN (1-607): 1.73e-146: 438: 100.00
+	Hs
		508000 DSC3_HUMAN (5-899): 0: 700: 30.32		FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29
+	Hs
		713804 DSC3_HUMAN (5-899): 0: 700: 30.32		RYK_HUMAN (1-607): 1.73e-146: 438: 100.00
+	Hs
		971016 DSC2_HUMAN (42-899): 0: 710: 30.46		NTRK2_HUMAN (36-607): 8.19e-131: 404: 22.24
+	Hs
		384675 DSC2_HUMAN (42-899): 0: 710: 30.46		NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65
+	Hs
		521694 CADH1_HUMAN (26-906): 0: 764: 45.71		SRC_HUMAN (315-602): 2.06e-108: 338: 30.80
+	Hs
		433230 CADH1_HUMAN (26-906): 0: 764: 45.71		YES_HUMAN (315-602): 3.09e-108: 337: 31.14
+	Hs
		411386 DSC3_HUMAN (5-899): 0: 700: 30.32		INSR_HUMAN (237-598): 1.43e-108: 357: 29.40
+	Hs
		433353 DSC3_HUMAN (5-899): 0: 700: 30.32		YES_HUMAN (315-602): 3.09e-108: 337: 31.14
+	Hs
		441414 CADH1_HUMAN (26-906): 0: 764: 45.71		MET_HUMAN (265-593): 1.87e-59: 217: 35.95
+	Hs
		441505 DSC3_HUMAN (5-899): 0: 700: 30.32		MET_HUMAN (265-593): 1.87e-59: 217: 35.95
+	Hs
		987245 DSC3_HUMAN (5-899): 0: 700: 30.32		TYRO3_HUMAN (315-592): 1.89e-53: 198: 37.50
+	Hs
		435643 DSC3_HUMAN (5-899): 0: 700: 30.32		IGF1R_HUMAN (325-598): 2.72e-50: 189: 34.42