HitPredict

Interactor 1: CADH2 (P19022)
Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)
Gene: CDH2

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 839
+	Hs
		384238 CADH2_HUMAN (1-906): 0: 998: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		507842 CADH2_HUMAN (1-906): 0: 998: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		1055826 DSC3_HUMAN (5-899): 0: 700: 30.32		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		434134 CADH2_HUMAN (1-906): 0: 998: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		971016 DSC2_HUMAN (42-899): 0: 710: 30.46		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		507817 CADH1_HUMAN (26-906): 0: 764: 45.71		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		580239 CADH2_HUMAN (1-906): 0: 998: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		580228 CADH2_HUMAN (1-906): 0: 998: 100.00		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		435531 CADH2_HUMAN (1-906): 0: 998: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		384675 DSC2_HUMAN (42-899): 0: 710: 30.46		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		508000 DSC3_HUMAN (5-899): 0: 700: 30.32		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		521969 CADH1_HUMAN (26-906): 0: 764: 45.71		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		521890 CADH1_HUMAN (26-906): 0: 764: 45.71		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		1055828 DSC3_HUMAN (5-899): 0: 700: 30.32		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		411386 DSC3_HUMAN (5-899): 0: 700: 30.32		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435643 DSC3_HUMAN (5-899): 0: 700: 30.32		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		537741 DSC3_HUMAN (5-899): 0: 700: 30.32		INSRR_HUMAN (513-820): 1.33e-62: 231: 40.84
+	Hs
		435534 CADH3_HUMAN (6-906): 0: 675: 41.24		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		384817 DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		507992 DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43