HitPredict

Interactor 1: ML12A (P19105)
Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)
Gene: MYL12A

Interactor 2: MYLK (Q15746)
Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]
Gene: MYLK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21457715
Identification Methods	protein kinase assay
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	EF-hand_7~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 171 Hs			1 1914
+	Hs
		159577 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYLK_HUMAN (1-1900): 0: 1463: 100.00
+	Hs
		624354 MYL9_HUMAN (14-171): 2.29e-64: 196: 94.30		MYLK_HUMAN (1-1900): 0: 1463: 100.00
+	Dm
		773033 SQH_DROME (1-171): 2.38e-60: 186: 80.46		Q95SK9_DROME (1439-1721): 1.24e-88: 298: 48.78
+	Dm
		825619 CALL_DROME (101-170): 9.67e-12: 61.3: 32.86		KCC2A_DROME (1459-1805): 6.55e-127: 411: 31.65
+	Hs
		648500 CALL3_HUMAN (31-92): 1.25e-10: 58.2: 27.27		KCC1A_HUMAN (1458-1770): 2.35e-129: 411: 35.76
+	Hs
		648542 CALL3_HUMAN (31-92): 1.25e-10: 58.2: 27.27		KCC1D_HUMAN (1448-1768): 1.43e-128: 410: 34.88
+	Hs
		483929 CALM1_HUMAN (16-92): 3.58e-09: 54.5: 24.69		KCC1A_HUMAN (1458-1770): 2.35e-129: 411: 35.76
+	Dm
		906661 CALM_DROME (16-92): 3.58e-09: 54.5: 27.16		KCC2A_DROME (1459-1805): 6.55e-127: 411: 31.65
+	Hs
		159558 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		DAPK1_HUMAN (1452-1759): 1.67e-71: 267: 44.06
+	Hs
		483947 CALM1_HUMAN (16-92): 3.58e-09: 54.5: 24.69		KCC1D_HUMAN (1448-1768): 1.43e-128: 410: 34.88
+	Hs
		483928 CALM1_HUMAN (16-92): 3.58e-09: 54.5: 24.69		KCC2D_HUMAN (1456-1801): 1.11e-126: 409: 30.73
+	Hs
		484002 CALM2_HUMAN (16-92): 3.58e-09: 54.5: 24.69		KCC2D_HUMAN (1456-1801): 1.11e-126: 409: 30.73
+	Hs
		484120 CALM3_HUMAN (16-92): 3.58e-09: 54.5: 24.69		KCC2D_HUMAN (1456-1801): 1.11e-126: 409: 30.73
+	Hs
		159518 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		DAPK3_HUMAN (1457-1742): 3.15e-74: 257: 43.09
+	Ce
		183804 CALM_CAEEL (16-92): 2.97e-09: 54.5: 27.16		CMK1_CAEEL (1460-1780): 9.61e-125: 398: 36.92
+	Gg
		361267 MLRM_CHICK (14-171): 1.05e-63: 194: 93.67		MYLK_CHICK (1094-1189): 7.12e-10: 66.5: 22.68
+	Dm
		906677 CALM_DROME (16-92): 3.58e-09: 54.5: 27.16		Q7JMV3_DROME (1454-1765): 1.12e-55: 201: 35.42
+	Dm
		54870 CALM_DROME (16-92): 3.58e-09: 54.5: 27.16		A1ZA72_DROME (1707-1887): 5.65e-10: 67.3: 17.13