HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: ASAP1 (Q9ULH1)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
Gene: ASAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.770

Property	Details
Experiments	17474147
Identification Methods	anti tag coimmunoprecipitation, peptide array, pull down, anti bait coimmunoprecipitation, fluorescence technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	ArfGap~PH, BAR_3~PH, PH~PH, PH~SH3_9, Ank_2~SH3_1, PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0098978 - glutamatergic synapse
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 1290 Hs			1 1129
+	Hs
		195785 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Rn
		499164 PLCG1_RAT (1-1290): 0: 1299: 96.90		AGAP2_RAT (379-660): 5.08e-87: 308: 29.02