HitPredict

Interactor 1: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Interactor 2: SRPK3 (Q9UPE1)
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)
Gene: SRPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	23602568
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 710 Hs			1 567
+	Hs
		582218 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		582140 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		GSK3B_HUMAN (23-336): 1.58e-67: 226: 16.87
+	Hs
		582446 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		516362 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		516460 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		942631 PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		833945 PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		516419 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		GSK3B_HUMAN (23-336): 1.58e-67: 226: 16.87
+	Hs
		516416 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		582139 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		CLK1_HUMAN (405-566): 8.71e-11: 66.2: 26.01
+	Hs
		516651 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Rn
		78186 B5DF80_RAT (221-482): 9.65e-44: 169: 15.99		MK03_RAT (75-267): 1.43e-44: 164: 20.90
+	Rn
		600488 PABP1_RAT (222-482): 5.13e-43: 167: 15.55		MK03_RAT (75-267): 1.43e-44: 164: 20.90
+	Sc
		694216 PUB1_YEAST (475-648): 4.1e-16: 83.6: 28.89		SKY1_YEAST (10-266): 1.03e-71: 245: 40.23
+	Rn
		102586 G3V9N0_RAT (222-488): 1.24e-41: 163: 14.53		MK03_RAT (75-267): 1.43e-44: 164: 20.90
+	Hs
		834096 PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		516417 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		834033 PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97