HitPredict

Interactor 1: RPAB1 (P19388)
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)
Gene: POLR2E

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 20371770
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0050821 - protein stabilization GO:1990062 - RPAP3/R2TP/prefoldin-like complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 210 Hs			1 456
+	Mm
		888080 RPAB1_MOUSE (1-210): 3.79e-102: 295: 98.57		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		583842 RPAB1_HUMAN (1-210): 1.63e-101: 293: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		593183 RPAB1_YEAST (2-208): 1.31e-77: 233: 43.66		RUVB1_YEAST (1-455): 0: 652: 67.39