HitPredict

Interactor 1: ELK1 (P19419)
ETS domain-containing protein Elk-1
Gene: ELK1

Interactor 2: MK03 (P27361)
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
Gene: MAPK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.60 0.754

The method score is based on:

Property Details
Experiments 34497368, 16998585, 29259132, 20371703, 15782123, 15967991, 14499342, 16291755
Identification Methods pull down, enzymatic study, affinity chromatography technology, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 428
Hs

1 379
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024