HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26212014
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0010803 - regulation of tumor necrosis factor-mediated signaling pathway GO:0042742 - defense response to bacterium
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 455 Hs			1 635
+	Mm
		626854 TNR1A_MOUSE (1-445): 4.25e-127: 377: 64.37		KSYK_MOUSE (1-635): 0: 567: 92.13
+	Hs
		522761 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		337916 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		154297 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		665365 EDAR_HUMAN (27-450): 4e-77: 249: 14.32		EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83
+	Hs
		584315 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		JAK1_HUMAN (312-632): 4.51e-39: 156: 20.81
+	Hs
		507889 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		154294 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		436626 TNR16_HUMAN (40-303): 1.33e-29: 121: 18.46		NTRK2_HUMAN (158-631): 7.36e-116: 366: 24.27
+	Hs
		154290 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		411601 TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21		LCK_HUMAN (5-201): 3.03e-71: 240: 23.29
+	Hs
		522788 TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		616887 EDAR_HUMAN (27-450): 4e-77: 249: 14.32		JAK1_HUMAN (312-632): 4.51e-39: 156: 20.81
+	Hs
		412024 TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		433256 TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21		YES_HUMAN (4-203): 1.25e-68: 234: 20.80
+	Hs
		339213 TNR11_HUMAN (43-368): 2.49e-47: 174: 16.43		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		383920 TR19L_HUMAN (61-342): 3.05e-34: 134: 15.64		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		616848 TR19L_HUMAN (61-342): 3.05e-34: 134: 15.64		JAK1_HUMAN (312-632): 4.51e-39: 156: 20.81
+	Hs
		632219 TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21		BMX_HUMAN (15-193): 8.37e-12: 70.3: 22.82
+	Hs
		591286 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		BMX_HUMAN (15-193): 8.37e-12: 70.3: 22.82