HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19641494
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 455 Hs			1 192
+	Hs
		584359 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436154 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		154338 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		154305 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		154300 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		154414 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		154332 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		154343 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		154333 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		154335 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		154295 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		121470 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		121438 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		121436 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		121534 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		121464 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		121472 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		121466 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		121467 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		121431 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45