HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.766

The method score is based on:

Property Details
Experiments 30561431, 26212014, 27321185, 28388439, 30420664, 29108854, 31406107, 32968279, 8612133, 8565075, 8943045, 34839354, 19815541, 22179575, 20448643, 18776134, 11821416, 20333651, 15743837, 16611992 and 4 others

more...
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation, virotrap
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002947 - tumor necrosis factor receptor superfamily complex
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0043120 - tumor necrosis factor binding
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0045121 - membrane raft
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024