HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30420664
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 455 Hs			1 716
+	Hs
		584494 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		158391 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Hs
		167467 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Mm
		291437 TNR1A_MOUSE (1-445): 4.25e-127: 377: 64.37		IKKB_MOUSE (9-701): 1.41e-126: 395: 19.10
+	Mm
		626859 TNR1A_MOUSE (1-445): 4.25e-127: 377: 64.37		IKKA_MOUSE (9-700): 5.3e-115: 365: 18.72
+	Hs
		158417 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Hs
		738710 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		TAOK2_HUMAN (2-702): 7.63e-113: 370: 15.59
+	Hs
		167489 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Mm
		291439 TNR5_MOUSE (43-326): 7e-52: 178: 20.63		IKKB_MOUSE (9-701): 1.41e-126: 395: 19.10
+	Hs
		158399 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Mm
		648957 TNR5_MOUSE (43-326): 7e-52: 178: 20.63		IKKA_MOUSE (9-700): 5.3e-115: 365: 18.72
+	Hs
		167470 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Hs
		167474 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Hs
		158372 TNR16_HUMAN (40-303): 1.33e-29: 121: 18.46		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Mm
		291445 TNR4_MOUSE (52-252): 2.35e-32: 125: 17.91		IKKB_MOUSE (9-701): 1.41e-126: 395: 19.10
+	Mm
		812912 TNR4_MOUSE (52-252): 2.35e-32: 125: 17.91		IKKA_MOUSE (9-700): 5.3e-115: 365: 18.72
+	Hs
		167447 TNR16_HUMAN (40-303): 1.33e-29: 121: 18.46		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31