HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32690868
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0016020 - membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 455 Hs			1 903
+	Hs
		154403 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1294870 TNR19_HUMAN (44-192): 3.25e-23: 103: 21.57		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1327919 TNR19_HUMAN (44-192): 3.25e-23: 103: 21.57		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		1299643 TNR19_HUMAN (44-192): 3.25e-23: 103: 21.57		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		808287 TNR19_HUMAN (44-192): 3.25e-23: 103: 21.57		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Mm
		648952 TNR5_MOUSE (43-326): 7e-52: 178: 20.63		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38
+	Hs
		591415 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94