HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 25416956, 31160341, 32296183, 11331580, 32051585, 29667579, 32796032, 33619271, 36807144, 16403452, 18022694, 21045130, 17156811, 15916807, 16297862, unassigned1304, 22493164, 22829933
Identification Methods two hybrid, pull down, affinity chromatography technology, enzymatic study, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PRY~PRY, PRY~SPRY, SPRY~SPRY, zf-B_box~zf-B_box, zf-B_box~zf-C3HC4
Common GO terms GO:0000209 - protein polyubiquitination
GO:0000932 - P-body
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding
and 42 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 475
Hs

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Last updated: 15 Jul 2024