HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25416956, 32296183
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 158
+	Hs
		584907 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		584923 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Hs
		584916 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		584994 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		Q7KZS0_HUMAN (1-137): 2.27e-71: 214: 100.00
+	Hs
		584910 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12
+	Hs
		1336390 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42
+	Hs
		849453 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		919870 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Hs
		895921 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		895815 TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		1297370 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E2_HUMAN (3-156): 7.29e-69: 208: 33.77
+	Hs
		849406 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		1282350 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E3_HUMAN (3-156): 2.14e-68: 207: 33.77
+	Hs
		919822 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Hs
		851889 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12
+	Hs
		895876 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		536760 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		895851 TRI58_HUMAN (1-472): 1.06e-141: 416: 43.52		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		851867 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12
+	Hs
		536757 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UBE2A_HUMAN (1-154): 3.37e-67: 202: 41.56