HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 0.60 0.743

The method score is based on:

Property Details
Experiments 26347139, 26043024, 34921137, 19201866, 26942676, 31852783, 36692217
Identification Methods pull down, affinity chromatography technology, enzymatic study
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000932 - P-body
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005776 - autophagosome
GO:0005829 - cytosol
and 3 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 475
Hs

1 440
+ Hs
+ Hs
+ Hs
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+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024