HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: LNX1 (Q8TBB1)
E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
Gene: LNX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	zf-B_box~zf-C3HC4
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 475 Hs			1 728
+	Hs
		1252493 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		1149890 TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		536942 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		1115440 TRI60_HUMAN (1-469): 8.83e-134: 396: 34.17		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		1204896 TRI50_HUMAN (1-461): 1.37e-120: 363: 26.74		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		1252534 TRI10_HUMAN (1-453): 6.58e-114: 345: 30.75		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		1020183 TRI72_HUMAN (1-465): 4.21e-106: 325: 26.09		PTN13_HUMAN (455-725): 4.02e-23: 107: 15.44