HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: RN125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Gene: RNF125

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35710093
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0008270 - zinc ion binding GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 475 Hs			1 232
+	Hs
		584870 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		RO52_HUMAN (22-227): 1.26e-41: 149: 13.30
+	Hs
		585075 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		TRI39_HUMAN (28-229): 3.66e-38: 140: 16.90
+	Hs
		585057 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		585058 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		TRIM5_HUMAN (24-229): 2.94e-33: 126: 15.81
+	Hs
		536726 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		585019 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17
+	Mm
		1112402 RO52_MOUSE (3-467): 1.33e-154: 449: 69.68		Q3U7K7_MOUSE (27-227): 1.19e-39: 143: 16.36
+	Hs
		1283424 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		RN166_HUMAN (1-224): 1.46e-42: 145: 30.83
+	Hs
		1336382 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		TRI39_HUMAN (28-229): 3.66e-38: 140: 16.90
+	Hs
		1336392 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		TRI17_HUMAN (22-226): 6.96e-35: 131: 15.32
+	Hs
		1149881 TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62		TRI68_HUMAN (22-221): 5.24e-36: 134: 15.94
+	Hs
		1290865 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		TRI11_HUMAN (22-215): 2.41e-33: 126: 15.50
+	Hs
		536980 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		1290906 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		TRI35_HUMAN (18-229): 2.74e-32: 124: 12.67
+	Hs
		1245269 TRI58_HUMAN (1-472): 1.06e-141: 416: 43.52		TRI58_HUMAN (22-231): 8.08e-34: 128: 15.95
+	Hs
		1252493 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17
+	Hs
		1149890 TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17
+	Hs
		129529 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		TRAF5_HUMAN (8-176): 3.95e-29: 116: 23.81