HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: AGO4 (Q9HCK5)
Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)
Gene: AGO4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	36371565, 19167051
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 475 Hs			1 861
+	Hs
		585070 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		AGO3_HUMAN (5-861): 0: 1146: 81.18
+	Hs
		1290902 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		AGO2_HUMAN (12-861): 0: 1151: 78.94
+	Hs
		1261113 TRI41_HUMAN (1-44): 3.5e-10: 64.1: 45.83		AGO4_HUMAN (1-861): 0: 1180: 100.00