HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: TRI39 (Q9HCM9)
E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)
Gene: TRIM39

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.911

The method score is based on:

Property Details
Experiments 25416956, 32296183, 22493164, unassigned1304
Identification Methods two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PRY~PRY, PRY~SPRY, SPRY~SPRY, zf-B_box~zf-B_box, zf-B_box~zf-C3HC4
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination
and 1 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 475
Hs

1 518
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024