HitPredict

Interactor 1: TFEB (P19484)
Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)
Gene: TFEB

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 23444366
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 476 Hs			1 245
+	Hs
		585111 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		585113 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		585108 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Mm
		910264 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Mm
		926809 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00
+	Mm
		933128 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433T_MOUSE (1-245): 2.96e-141: 397: 99.59
+	Hs
		585630 TFE3_HUMAN (4-472): 5.79e-65: 221: 44.65		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		252914 MITF_HUMAN (1-461): 1.67e-65: 221: 40.64		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		585115 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		252907 MITF_HUMAN (1-461): 1.67e-65: 221: 40.64		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		585110 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Mm
		1144939 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433B_MOUSE (1-242): 2.84e-124: 354: 80.99
+	Hs
		647289 MLXIP_HUMAN (33-350): 1.28e-35: 142: 14.71		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		683723 MLXIP_HUMAN (33-350): 1.28e-35: 142: 14.71		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Mm
		250872 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433S_MOUSE (1-232): 2e-106: 309: 72.65
+	Mm
		935516 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433F_MOUSE (2-242): 4.62e-106: 308: 71.43
+	Hs
		252919 MITF_HUMAN (1-461): 1.67e-65: 221: 40.64		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Mm
		905346 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433G_MOUSE (1-242): 5.48e-105: 305: 70.33
+	Hs
		252912 MITF_HUMAN (1-461): 1.67e-65: 221: 40.64		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		585644 TFE3_HUMAN (4-472): 5.79e-65: 221: 44.65		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33