HitPredict - High confidence protein-protein interactions

Interactor 1: E2AK2 (P19525)
Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
Gene: EIF2AK2

Interactor 2: E2AK2 (P19525)
Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
Gene: EIF2AK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.986

Property	Details
Experiments	18082144, 12882984, 29070839, 7568151, 10848580, 24659800, 26488609, 16785445, 26216977, 14585331, 11447118, 16373505, 10390359, 9143277
Identification Methods	enzymatic study, pull down, two hybrid, far western blotting, affinity chromatography technology, fluorescent resonance energy transfer, x-ray crystallography, protein kinase assay
Interaction Type	direct interaction, physical association, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	dsrm~dsrm, Pkinase~Pkinase
Common GO terms	GO:0001819 - positive regulation of cytokine production GO:0003723 - RNA binding GO:0003725 - double-stranded RNA binding GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity and 36 others more... GO:0004694 - eukaryotic translation initiation factor 2alpha kinase activity GO:0004715 - non-membrane spanning protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005840 - ribosome GO:0006412 - translation GO:0006468 - protein phosphorylation GO:0008285 - negative regulation of cell population proliferation GO:0009615 - response to virus GO:0016020 - membrane GO:0016301 - kinase activity GO:0017148 - negative regulation of translation GO:0019888 - protein phosphatase regulator activity GO:0030968 - endoplasmic reticulum unfolded protein response GO:0032722 - positive regulation of chemokine production GO:0032874 - positive regulation of stress-activated MAPK cascade GO:0033689 - negative regulation of osteoblast proliferation GO:0034198 - cellular response to amino acid starvation GO:0035455 - response to interferon-alpha GO:0043066 - negative regulation of apoptotic process GO:0043410 - positive regulation of MAPK cascade GO:0045071 - negative regulation of viral genome replication GO:0046777 - protein autophosphorylation GO:0048471 - perinuclear region of cytoplasm GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0051607 - defense response to virus GO:0106310 - protein serine kinase activity GO:0140374 - antiviral innate immune response GO:1900225 - regulation of NLRP3 inflammasome complex assembly GO:1901224 - positive regulation of non-canonical NF-kappaB signal transduction GO:1901532 - regulation of hematopoietic progenitor cell differentiation GO:1902033 - regulation of hematopoietic stem cell proliferation GO:1902036 - regulation of hematopoietic stem cell differentiation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	551
Hs

1	551

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Last updated: 15 Jul 2024