HitPredict

Interactor 1: E2AK2 (P19525)
Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
Gene: EIF2AK2

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	31478661, 7738010
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 191
+	Rn
		448411 KPCD_RAT (43-548): 4.78e-132: 401: 14.67		RAC1_RAT (1-191): 1.75e-84: 249: 70.31
+	Hs
		564505 PAK1_HUMAN (24-549): 4.55e-127: 384: 16.25		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		900406 KPCD_HUMAN (43-548): 7.52e-133: 403: 15.77		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		436269 KPCD_HUMAN (43-548): 7.52e-133: 403: 15.77		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		1026226 PAK1_HUMAN (24-549): 4.55e-127: 384: 16.25		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Mm
		103566 G5E884_MOUSE (50-549): 8.65e-128: 386: 16.57		RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31
+	Hs
		925244 PAK1_HUMAN (24-549): 4.55e-127: 384: 16.25		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Mm
		103565 G5E884_MOUSE (50-549): 8.65e-128: 386: 16.57		CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00
+	Rn
		723755 PAK1_RAT (50-549): 7.85e-128: 386: 16.76		CDC42_RAT (1-191): 4.96e-82: 243: 100.00
+	Mm
		292040 PAK1_MOUSE (50-549): 2.81e-125: 379: 16.16		RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31
+	Hs
		893957 PAK1_HUMAN (24-549): 4.55e-127: 384: 16.25		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		950963 PAK1_HUMAN (24-549): 4.55e-127: 384: 16.25		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Mm
		103567 G5E884_MOUSE (50-549): 8.65e-128: 386: 16.57		RAC2_MOUSE (1-191): 1.1e-80: 239: 69.27
+	Hs
		545350 PAK1_HUMAN (24-549): 4.55e-127: 384: 16.25		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Mm
		292039 PAK1_MOUSE (50-549): 2.81e-125: 379: 16.16		CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00
+	Mm
		292048 PAK1_MOUSE (50-549): 2.81e-125: 379: 16.16		RHOA_MOUSE (5-191): 9.99e-82: 242: 53.48
+	Mm
		292041 PAK1_MOUSE (50-549): 2.81e-125: 379: 16.16		RAC2_MOUSE (1-191): 1.1e-80: 239: 69.27
+	Hs
		892345 PAK1_HUMAN (24-549): 4.55e-127: 384: 16.25		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Mm
		103575 G5E884_MOUSE (50-549): 8.65e-128: 386: 16.57		RHOQ_MOUSE (4-191): 3.45e-73: 221: 64.62
+	Hs
		1026182 PAK1_HUMAN (24-549): 4.55e-127: 384: 16.25		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82