HitPredict

Interactor 1: E2AK2 (P19525)
Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
Gene: EIF2AK2

Interactor 2: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9447982
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 129
+	Hs
		470264 E2AK2_HUMAN (1-551): 1.25e-165: 483: 100.00		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		391541 E2AK2_HUMAN (1-551): 1.25e-165: 483: 100.00		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		408623 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00
+	Hs
		408674 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2AJ_HUMAN (1-129): 1.81e-66: 198: 96.90
+	Hs
		408661 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2A1H_HUMAN (1-127): 1.77e-65: 196: 96.06
+	Hs
		408665 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06
+	Hs
		408533 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		408631 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64
+	Hs
		408639 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2A3_HUMAN (1-127): 5.35e-65: 195: 95.28
+	Hs
		408656 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2A1C_HUMAN (1-127): 4.25e-65: 195: 96.06
+	Hs
		391498 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		408553 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2A1D_HUMAN (1-127): 6.03e-65: 194: 95.28
+	Hs
		555442 PAK1_HUMAN (24-549): 4.55e-127: 384: 16.25		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		408546 KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		851513 NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41		H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00
+	Hs
		470303 NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		851543 NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41		H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64
+	Hs
		391607 NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		594834 NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41		H2A1D_HUMAN (1-127): 6.03e-65: 194: 95.28
+	Hs
		555364 NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12