HitPredict

Interactor 1: E2AK2 (P19525)
Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
Gene: EIF2AK2

Interactor 2: EIF2A (Q9BY44)
Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]
Gene: EIF2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.725

Property	Details
Experiments	29070839, 18835251, 16179258, 26216977, 19229320, 22268531
Identification Methods	enzymatic study, x-ray crystallography, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 585
+	Hs
		1316100 E2AK4_HUMAN (330-549): 5.16e-25: 112: 35.04		EIF2A_HUMAN (1-573): 3.48e-165: 484: 100.00
+	Hs
		1316098 E2AK3_HUMAN (251-327): 1.35e-11: 69.7: 46.34		EIF2A_HUMAN (1-573): 3.48e-165: 484: 100.00
+	Hs
		851386 NEK3_HUMAN (266-533): 4.56e-24: 107: 27.60		KTNB1_HUMAN (2-141): 5.48e-15: 80.2: 11.27