HitPredict

Interactor 1: NFKB1 (P19838)
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Gene: NFKB1

Interactor 2: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 26186194, 26496610, 28514442, 11313474, 32912968, 33961781, 20980497, 20558726, 11020244, 17003112, 25609649, 27609421, 29439025, 22536447, 9738011, 33572115, 35140242, 35271311, 20237821, 8631829 and 12 others

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Identification Methods affinity chromatography technology, pull down, proximity labelling technology, two hybrid, tandem affinity purification, anti bait coimmunoprecipitation, electrophoretic mobility supershift assay, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank~Ank_2, Ank~Ank_5, Ank_2~Ank_2, Ank_2~Ank_5, Ank_2~RHD_dimer
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process
and 8 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024